General Anesthetics

Apr 6th, 2015
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This is a PPT presentation of general Anesthetics

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1GENERALANAESTHETICSHistory2Attempts to suppress pain of surgery by ofdrugs included use of ethanol and opiates.William Morton used diethyl ether in 1846.James Simpson used chloroformNitrous oxide which had been suggested bydavy in the 1790s was introduced in the1860s.1930s, IV Barbiturates-thiopentalThen curare for muscle relaxation.History3Attempts to suppress pain of surgical by use ofdrugs included use of ethanol and opiates.William morton used diethyl ether in 1846.James simpson used chloroform,Then nitrous oxide had been suggested byDavy in1790s.1930s IV barbiturates-thiopental.Then curare for muscle relaxation.Contd41st Modern halogenated hydrocarbon halothane was introduced as an inhaledanaesthetic in 1956.Contd5State of general anaesthesia includesanalgesia, amnesia, loss of consciousness,inhibition of sensory and autonomic reflexesand skeletal muscle relaxation.Ideal anaesthetic agent6Smooth and rapid induction of anaesthesia.Permit rapid recoveryWide margin of safetyDevoid of adverse effectsPleasant, non irritantLow blood/gas solubilityChemically stableNeither flammable/nor explosiveContd.7Not metabolised in the body, non toxic, noallergic reactionsEasy to administer in standard vaporisersNot eliptogenic/doe not increase intracranialpressureProtocols8Depend on the

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