Types of anesthesis

Apr 8th, 2015
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this is a PPT study guide on the different types of anesthesia

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approach Classify Pharmacokinetics Pharmacodynamics Clinical uses New frontiers.Classification if intravenousanesthetics RAPID ACTING (primary induction agents) Barbiturates:MethohexitalThiobarbiturates (thiopental, thiamylal)Older drugs (Amobarbital/Pentobarbital) Imidazoles Etomidate* Sterically hindered alkyl phenols Propofol* Steroids Althesin,minaxolone,eltanolone Eugenols PropanididCont Slow acting (basal narcotic agents) Ketamine* Benzodiazepines*diazepam.,flunitrazepam,midazolam Opioids*Fentanyl,alfentanyl,sufentanyl,remifentanyl NeurolepticshaloperidolPharmacokinetics of intravenousagents Protein binding: only unbound drug crosses bloodbrain barrier. low plasma proteins, high blood p.hincreases unbound drugCerebral blood flowPH and Pka of the drugLipid and water solubilitySpeed of injectionbarbiturates Thiopental sodium: Formulation:Sulphur analogue of pentobarbitalYellow powder, for dilution in water for injectionUnstable in diluted form after 24 hoursHas a faint garlic smellContd Pharmacokinetics: Administered as a 2.5% solution Highly protein bound 78-85% interacts with drugs like phenylbutazone Highly lipid soluble, fast onset and offset, cumulation on continousinfusion Metabolised mainly in liver by zero order kinetics and metabolitesexcrete

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