The role of dopamine

Apr 8th, 2015
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PPT study guide on the role of dopamine

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Cryptococcal MeningitisIntroduction C. neoformans is the leading infectious causeof meningitis in patients with AIDS It is the initial AIDS-defining illness inapproximately 2% of patients generally occurs in patients with CD4+ T cellcounts <100/uL.Etiologic agent Cryptococcosis is an infection caused by theyeast like fungus Cryptococcus neoformans.EPIDEMIOLOGY Weathered pigeon droppings commonly containserotype A or D (C. neoformans var. neoformans). Cryptococcosis due to C. neoformans var.neoformans is a common complication of lateinfection with HIV. Patients who have undergone solid-organtransplantation or glucocorticoid therapy andthose with sarcoidosis are also at increased riskfor infections with C. neoformans var.neoformans. . Almost all such infections are caused byserotype A, although serotype D occurs in upto 20% of cases in Western Europe. Animals, particularly cats, can acquirecryptococcosis but have not transmitted theinfection to other animals or to humans. Cryptococcosis is rare before pubertyPATHOGENESIS & PATHOLOGY Infection is thought to be acquired byinhalation of fungus into the lungs. Pulmonary infection has a tendency towardspontaneous resolution and is frequentlyasymptomatic. Silent hematogenous spread to the brain leadsto clusters of cryptococci in the perivascularareas of cortical gray matter, in the basalganglia, and, to a lesser extent, in other areasof the cent

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