Shigellosis: infectious disease

Apr 8th, 2015
Studypool Tutor
Price: $20 USD

Tutor description

Study guide on Shigellosis

Word Count: 245
Showing Page: 1/7
SHIGELLOSISBACILLARY DYSENTERY(SHIGELLOSIS)This is an acute infectious inflammatory colitis.Gram-negative rodsfour main groups: Sh. dysenteriae, flexneri, boydii andsonnei.Sh. Dysenteriae- most severe diseaseCulture- non-lactose fermenters (MacConkey &EMB), non-motile, non-H2S producers(TSI slant agar)EpidemiologyFecal- oral spread (5Fs) Although shigellae are found world-wide,transmission is strongly associated withpoor hygiene. More prevalent in the developing world,where the main burden falls onchildren( under 5) Only small numbers need to be ingestedto cause illness < 200 (i.e. very acidstable)Pathogenesis1.2.Invasive: Invade M cells, get into thecytoplasm,replicate & then polymerize actin jettrails & go laterally into adjacent cells withoutthe need to go back into the ECF. Thus RBCs& PMNs in stoolEndotoxin: (Shiga toxin). Produced by Sh.Dysenteriae type 1. Has 3 acivities :Neurotoxic, cytotoxic & enterotoxic. A-Btoxin. Inhibits protein synthesis by clippingthe 60S ribosomal subunit. Recall which othertoxin has a similar mode of action?Clinical features1-4 day incubation preiodDisease severity varies:1.Sh. sonnei infections- mild & may escape detection2.Sh. flexneri infections- more severe3.Sh. Dysenteriae-most severe form of dysentery may befulminating and cause death within 48 hoursDiarrhoea-mucus,bloody with PMNsColicky abdominal painTenesmusFever(

Review from student

Studypool Student
" Excellent work as usual "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1826 tutors are online

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors