Non steroidal anti-inflammatory drugs

Apr 8th, 2015
Studypool Tutor
Price: $20 USD

Tutor description

Study guide on NSAIDS

Word Count: 603
Showing Page: 1/52
Nonsteroidal Antiinflammatory Drugs (NSAIDs)Common therapeutic indicationsCommon adverse effectsDifferent pharmacokinetics and potencyDifferent chemical familiesCommon mechanism of action (cyclooxygenaseinhibition) Different selectivities to COX I and IISimilarities more striking than DifferencesCommon PharmacologicalEffects Analgesic (CNS and peripheral effect) mayinvolve non-PG related effects Antipyretic (CNS effect) Anti-inflammatory (except acetaminophen) duemainly to PG inhibition.Some shown to inhibit activation, aggregation, adhesionof neutrophils & release of lysosomal enzymes Some are UricosuricCommon Adverse Effects Platelet Dysfunction Gastritis and peptic ulceration with bleeding(inhibition of PG + other effects) Acute Renal Failure in susceptible Sodium+ water retention and edema Analgesic nephropathy Prolongation of gestation and inhibition oflabor. Hypersenstivity (not immunologic but due toPG inhibition)NSAIDLoss of PGI2 induced inhibition of LTB4 mediatedendothelial adhesion and activation of neutrophils Leukocyte-EndothelialInteractionsCapillaryObstructionProteases +Oxygen RadicalsIschemicCell InjuryEndo/EpithelialCell InjuryMucosal UlcerationThe Salicylates - Aspirin Effect on Respiration: triphasic1. Low doses: uncoupling phosphorylation CO2 stimulates respiration.2. Direct stimulation of respiratory center Hyperve

Review from student

Studypool Student
" AMAZING as always! "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1826 tutors are online

Brown University

1271 Tutors

California Institute of Technology

2131 Tutors

Carnegie Mellon University

982 Tutors

Columbia University

1256 Tutors

Dartmouth University

2113 Tutors

Emory University

2279 Tutors

Harvard University

599 Tutors

Massachusetts Institute of Technology

2319 Tutors

New York University

1645 Tutors

Notre Dam University

1911 Tutors

Oklahoma University

2122 Tutors

Pennsylvania State University

932 Tutors

Princeton University

1211 Tutors

Stanford University

983 Tutors

University of California

1282 Tutors

Oxford University

123 Tutors

Yale University

2325 Tutors