Rabies infection and management

Apr 8th, 2015
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Study guide on Rabies infection and management

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RABIESEU MBCHB 3DR D M KILLINGOINTRODUCTION An invariably lethal acute viral disease ofthe CNS that affects all mammals Caused by a bullet shaped single strandRNA virus Rhabdoviridae family, lyssagenus. There are at least 7 rabies relatedviruses in the genusEPIDEMIOLOGY In all regions of the world except antarctica,new zealand, japan, taiwan, sweden,norway, spain, hawaii Common in s.e. asia, the phillipines, africa,indian sub continent and tropical s. americaEPIDEMIOLOGY contd2 forms: urban rabies. Spread by unimmuniseddomestic dogs, cats Sylvatic rabies spread by wild game likeskunks, foxes, racoons, mongooses, wolvesand bats. Major source in the USTHE PATHOGEN Rhabdoviridae family, genus lyssa virus Bullet shaped virion containing a singlestranded rna genome that encodes 5structural proteins: 1. Outer glycoprotein primary target ofneutralising antibody 2. Nucleoprotein enables identification ofrabies virus variantsTHE PATHOGEN 3. Large polymerase protein 4. Phosphorylated protein 5. Matrix protein Each virion surrounded by a lipoproteinenvelop studded with glycoprotein spikeswhich attach to specific sites such asnicotinic Ach recs on plasma membranes ofmuscle cellsImmunohistochemical Staining (Red) of Rabies Virus Antigens inPeripheral Nerves of the Liver (Panels A and B), Kidney (Panel C),andArterial-Graft Transplants (Panel D).PATHOGENESIS I

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