Gonadal hormones and inhibitors

Apr 8th, 2015
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Study guide on Gonadal hormones and their inhibitors

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GONADAL HORMONESAND INHIBITORSTHE OVARY: ESTROGENS, PROGESTINS,OTHER OVARIAN HORMONES, ORALCONTRACEPTIVES, INHIBITORS,ANTAGONISTS & OVULATION INDUCINGAGENTS.1IntroOvary has important gametogenicfunctions involved with its hormonalactivity. The gonad becomes active duringpuberty. Menstrual cycle 30-40 days. Menopause: when it stops respondingto gonadotrophins secreted by theanterior pituitary gland :. Cyclicbleeding stops.2ContdThe maturation of centres in the brainmay withdraw an inhibition of the cellsof the median eminence of thehypothalamus, allowing them toproduce GnRH, which stimulates therelease of FSH and LH.3ContdInitially small amounts of FSH and LHare released and the estrogensecreted in response causes breastdevelopment, alterations in fatdistribution and a growth spurt thatculminates in epiphysial closure in thelong bones.4567ContdAfter 1 year, sufficient estrogen isproduced to induce endometrialchanges and periodic bleeding. At the beginning of each cyclevesicular follicles each containing anovum begin to enlarge in response toFSH. After 5-6 days, one of the folliclesdevelops more rapidly.89ContdThe granulosa cells of this folliclemultiple under the influence of LH,synthesize estrogens which appear toinhibit FSH release and may lead toregression of the smaller, less maturefollicles. Just before mid cycle the estrogenlevels reach a

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