Leshmaniasis Infection

Apr 8th, 2015
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Study guide on Leshmaniasis

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LEISHMANIASISOUTLINEIntroductionEtiologyClassificationEpidemiologyPathogenesisLeishmaniasis & HIVClinical featuresDiagnosisDDXTreatmentPreventionINTRODUCTION intracellular protozoan parasite of the genusLeishmaniaEndemic in the tropics, subtropics, and southernEurope; range from deserts to rain forests, from ruralto urban areas.Typically a vector-borne zoonosis, with rodentsand canids as common reservoir hosts and humansbeing incidental hosts.ETIOLOGYLeishmania are members of theTrypanosomatidae familyParasite is dimorphic, existing as aflagellate promastigote in the insect vectorand as an aflagellate amastigote in thehost.CLASSIFICATIONVisceral leishmaniasis L. donovani (E African, Sudan) L. donovani donovani (India) L. donovani infantum (Mediteranean regionSouthern Europe & N. Africa) L. donovani chagasi (S. America)Cutaneous leishmaniasis Old World:( S. Europe & N. Africa + E Africa, Asia) L. major L. tropica L. aethopicaClassification CL: New World (Central & South America) Two complexes: L. Braziliensis complex L. b. brasiliensis L. b. guyanensis L. b. panamensis L. Mexicana complex L. m. mexicana L. m. amazonensis L. m. venezuelensis Mucocutaneous leishmaniasis L. b. brasiliensis L. b. panamensisEPIDEMIOLOGYDse exists where insect vector, the Phlebotomitesandfly, and a mammal res

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