Gout presentation and management

Apr 8th, 2015
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Study guide on Gout presentation and managent

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GOUT1INTRODUCTION Gout is a true crystal depositiondisease. Crystals can deposit in andaround joints and areassociated with both acuteinflammatory and chronicsyndromes.2Factors influencing crystalformation1. Sufficient concentration of thechemical components.2. Crystal formation depends on thebalance of tissue factors thatpromote or inhibit crystalnucleation and growth. Because of their hard particulate3nature they may alsomechanically damage the tissuesin which they lie.GOUT True crystal deposition disease. Pathological reaction of the joint4or periarticular tissues to thepresence of monosodium uratemonohydrate (MSUM) crystals. Present as inflammatoryarthritis; bursitis; tenosynovitis;cellulitis; or as nodularContd Metabolic disease characterised byrecurrent episodes of acute arthritisdue to deposits of monosodiumurate in joints and cartilage. Is associated with high serum levels5of uric acid; a poorly solublesubstance that is a major endproduct of purine metabolism.Epidemiology 1% of the population Strong male predominance (>10:1) Prevalence increases with age. Increasing serum uric acidconcentration.6Contd 10 gout : exclusively a maledisease7: commonest cause ofinflammatory arthritisin men>40 20 gout : due to renal impairmentor drugtherapy.: age >65 years: form usually seen inwomenEtiology and pathogenesis 1/3 of the bodys ur

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