Synthetic statins

Apr 8th, 2015
Studypool Tutor
Price: $20 USD

Tutor description

Study guide on synthetic statins

Word Count: 487
Showing Page: 1/8
SYNTHETICSTATINS.These statins are the most effective and best-toleratedagentsfor treating dyslipidemia.SYNTHETICSTATINS. They are competitive inhibitors of 3-hydroxy-3A.K.A TYPE TWO STATINS.methylglutaryl coenzyme A (HMG-CoA) reductase.EXAMPLES OF SYTHETIC STATINS.AtorvastatinRosuvastatinFluvastatinCeruvastatinThis are structurally distinct synthetic compounds,fluvastatin, atorvastatin, rosuvastatin are fluorinecontaining congeners that are active as they are givenPHARMACOKINETICS.Absorption, Distribution, Metabolism, and Excretion ABSORPTION: After oral administration, intestinalabsorption of the statins varies between 30% and 85%.with the exception of fluvastatin, which is almostcompletely absorbed DISTRIBUTION: Due to extensive first-pass hepaticuptake, systemic bioavailability of the statins and theirhepatic metabolites varies between 5% and 30% ofadministered doses In the plasma, >95% of synthetic statins and theirmetabolites are protein bound After oral dosing, plasma concentrations of statins peak in14 hours. Plasma half-lives of these drugs range from 1 hour to 3hours except for atorvastatin, which has a half-life of 14hours, and rosuvastatin, 19 hours which may contributeto their greater cholesterol-lowering efficacyPHARMACOKINETICS.Absorption, Distribution, Metabolism, and Excretion METABOLISM: The catabolism of atorvastatinproceeds chiefly through CYP3A4, whereas that offlu

Review from student

Studypool Student
" Goes above and beyond expectations ! "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1822 tutors are online

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors