Anabolic steroid and androgens

Apr 8th, 2015
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Study guide on Anabolic steroids and androgens

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1ANDROGENS ANDANABOLIC STEROIDSIntroduction2The important androgen secreted by the testisis testosterone.In men ~8mg of testosterone is produced daily.95% is produced by the leydig cells and only5% in the adrenal.Contd3Testis also secretes small amounts of anotherpotent androgen, dihydrotestosterone aswell as androstenedione, anddehydroepiandrosterone, which are weakandrogens.Pregnenolone and progesterone and their17-hydroxylated derivatives are also releasedin small amounts.Contd4Plasma levels of testosterone in males areabout 0.6 g/dL after puberty and appear todecline after 55 years.In women 0.03g/dL from the ovaries,adrenals, and conversion of other hormones.65% of circulating testosterone is bound to sexhormone-binding globulin(SHBG).most of the remaining is bound to albumin.56Distribution of gonadal steroids and cortisol inplasma% Bound toSteroid% Free CBG GBG AlbuminTestosterone206533AndrostenedioneEstradiolProgesterone70885220183806080Cortisol490061 CBG, corticosteroid-binding globulin; GBG,gonadal steroid-binding globulin. (Courtesy of SMunroe.)7Metabolism8Testosterone is converted todihydrotestosterone by the enzyme 5reductase.Degradation occurs in the liver, and it leads to theproduction of inactive substances such asandrosterone and etiocholanolone that areconjugated and excreted in urine.Contd

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