Acquired diseases of bone development

Apr 8th, 2015
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ACQUIRED DISEASES OF BONE DEVELOPMENT Many nutritional, endocrine, and systemic disorders affect the skeletal system. Nutritional deficiencies causing bone disease include deficiencies of vitamin C (involved in collagen cross-linking; deficiency causes scurvy) and vitamin D (involved in calcium uptake; deficiency causes rickets and osteomalacia). Both of these are discussed in greater detail with other nutritional diseases . Primary and secondary hyperparathyroidism also cause significant skeletal changes, which will be briefly reviewed in this section. The major focus of the discussion here will be osteoporosis, resulting from a loss of bone mass, and Paget disease, a disease associated with the loss of osteoclast function. Osteoporosis Osteoporosis is a disease characterized by increased porosity of the skeleton resulting from reduced bone mass. It is associated with an increase in bone fragility and susceptibility to fractures. The disorder may be localized to a certain bone or region, as in disuse osteoporosis of a limb, or may involve the entire skeleton, as a manifestation of a metabolic bone disease.Generalized osteoporosis may be primary, or secondary to a large variety of conditions. Categories of Generalized OsteoporosisBody_ID: NonePrimaryBody_ID: T021001.50PostmenopausalBody_ID: T021001.100SenileBody_ID: T021001.150SecondaryBody_ID: T021001.200ENDOCRINE DISORDERSBody_ID: T021001.250HyperparathyroidismBody_ID: T021001.300Hypo or hy

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