Multiple Myeloma

Apr 8th, 2015
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Multiple Myeloma

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MULTIPLE MYELOMA (MM)Features MM is a malignant tumor of plasma cells that causes widespread osteolytic bone damage Most common primary malignant tumor of bone (~ 40%) May affect any bone with hematopoietic red marrow (spine, skull, ribs, sternum and pelvis) Age 50-80 year M:F 2:1 Presentation bone pain related to the deposits Pathological fractures Constitutional symptoms related to anemia, thrombocytopenia and renal failure Other symptoms may include cachexia, spinal cord compression Amyloidosis in 20% Bacterial infections are common because of a lack of normal immunoglobulin

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