Jul 8th, 2015
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Kaplan University
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PANCREATITISDR ANN MULIDEFINITIONPancreatitis - inflammation of the pancreas.CLASSIFICATIONSeither acute or chronic.Acute pancreatitis refers to an acute inflammationthat resolves both clinically and histologicallyChronic pancreatitis is characterized byirreversiblehistologic changes that persist even after the causehas been removed.The histologic changes in chronic pancreatitis tend toprogress, resulting in serious loss of exocrine andendocrine pancreatic function and deterioration ofpancreatic structure.ANATOMY &PHYSIOLOGYThe pancreas is a gland located in the upper, posteriorabdomen and is responsible for insulin production(endocrine pancreas) & the manufacture and secretionof digestive enzymes (exocrine pancreas) leading tocarbohydrate, fat, and protein metabolism.Approximately 80% of the gross weight of thepancreas supports exocrine function, while theremaining 20% is involved with endocrine function.ANATOMY &PHYSIOLOGY.Enzymes are produced within the pancreatic acinarcells, packaged into storage vesicles called zymogens,and then released via the pancreatic ductal cells intothe pancreatic duct, where they are secreted into thesmall intestine.up to 15 different types of digestive enzymes aremanufactured in the rough endoplasmic reticulum,targeted in the golgi apparatus & packaged intozymogens as pro-enzymes.When a meal is ingested, the vagal nerves, VIP, GRP,secretin, CCK, and encephalins stimulate enzymaticrelease into the

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