Pharmacology notes

Apr 15th, 2015
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Pharmacology notes

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Inherited Disorders of Amino AcidMetabolism in Adults: IntroductionINTRODUCTION Proteins are end products of most informationpathway, made up of carbon; hydrogen;oxygen; nitrogen; and some cases sulfur. A typical cell requires thousands of differentprotein at any given time Proteins must be synthesized in response tothe cells current needs, transported to theirappropriate cellular locations and degradedwhen no longer needed. Proteins are the only nutrients that containnitrogen, a fact that make it both essentialand potentially toxic. Amino acids are the building blocks ofproteins The sequence of the AAs and the secondaryand tertiary structures of the resultantproteins determine its function. There are about 20 amino acids of whichplants and some bacteria can synthesize all,but Humans can only synthesize about half ofthis. Therefore diet must supplement whatwe cannot synthesize i.e. essential aminoacids. Under certain conditions, some nonessentialAAs may become essential eg; advanced liverdse and prematurity, hence Cystein andtyrosine cannot be formed from their usualprecursors(methionine and phenylalanine)EssentialIsoleucineLeucineLysineMethioninePhenylalanineThreonineTryptophanValine Histidine ArginineNonessentialAlanineAspartateAsparagineCysteineGlutamineGlutamateGlycineProlineSerineTyrosineGlucogenic

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