Pharmacology notes

Apr 15th, 2015
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Pharmacology notes

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Lipid lowering drugsCholesterol: What is1it?Cholesterol is a fatty steroid made primarily in the liver ofmost animals and humans. It is an integral component in thesynthesis of hormones, can also be found in cell walls ofanimals and humans.Isolated cholesterol is a white, flaky solid that is insoluble inaqueous environments.CholesterolH OTwo types of transportation forcholesterolIn order to transport the steroid through blood, cholesterol isattached to a set of proteins called lipoproteins. There are twotypes of lipoproteins: high density and low density lipoproteins.HDL: High-density lipoproteins collect cholesterol particles as theytravel through blood vessels and deposits them in the liver wherethey are transferred to bile acids and disposed off.LDL: Low-density lipoproteins deposits on the walls of blood vessels,and over time, builds up into cholesterol plaque and blocks bloodvessels, especially arteries that feed blood to the heart.The liver manufactures, secretes and removes LDL cholesterol from thebody. To remove LDL cholesterol from the blood, there are special LDLreceptors on the surface of liver cells.1.2. LDL receptors remove LDL cholesterol particles from the blood and transportthem inside the liver. A high number of active LDL receptors on the liver surfaces isnecessary for the rapid removal of LDL cholesterol from the blood and low blood LDLcholesterol levels.A deficiency of LDL receptors is associated with high L

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