Pharmacology notes

Apr 15th, 2015
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Pharmacology notes

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1) True or False; a) Quinolones can enter cells easily via porins and therefore are often used to treat intracellular pathogens. b) For many gram-negative bacteria DNA gyrase is the target, whereas topoisomerase IV is the target for many gram-positive bacteria.c) Quinolones are well absorbed following oral administration.d) Quinolones are well distributed in the body tissues and mainly excreted unchanged by the kidneys and partly by the biliary route.e) Anaerobic bacteria respond very well to quinolones.2) The following statements are true except;a) Several derivatives of nitroimidazole antibiotics have been used to combat anaerobic bacterial and parasitic infections.b) Metronidazole is not useful in hepatic abscesses especially amoebic.. c) Alcoholic beverages can be consumed during Flagyl therapy. d) Adverse reactions in patients treated with metronidazole include convulsive seizures headache, dizziness, vertigo, incoordination, ataxia, confusion, e) Flagyl is contraindicated during the first trimester of pregnancy due to possible teratogenic effect.3) Which of the following statements are true concerning rifampicin;a) It is a bacteriostatic antibiotic drug of the rifamycin group.b) Rifampicin is typically used to treat mycobacterium infections, including tuberculosis and leprosy.c) Rifampicin is useful in prophylactic therapy against Neisseria meningitidis infection.d) It acts by inhibiting DNA-dependent RNA polymerasee) Rifampicin is an effect

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