Pharmacology notes

Apr 15th, 2015
Studypool Tutor
Price: $5 USD

Tutor description

Pharmacology notes

Word Count: 1050
Showing Page: 1/17
ANTIRETROVIRAL AGENTS Substantial advances have been made in antiretroviral therapy since theintroduction of the first agent, zidovudine, in 1987, and many antiretroviralagents are now available. In addition, greater knowledge of viral dynamics through the use of viral loadand resistance testing has made clear that combination therapy withmaximally efficacious and potent agents reduce viral replication to the lowestpossible level and decrease the likelihood of emergence of resistance. Thus,administration of highly active antiretroviral therapy (HAART), typicallycomprising a combination of 34 antiretroviral agents, has become thestandard of care. Such regimens may be composed of nucleoside reverse transcriptaseinhibitors, nonnucleoside reverse transcriptase inhibitors, protease inhibitors,and a fusion inhibitor.Viral susceptibility to specific agents varies among patients and may changewith time, owing to development of resistance.Therefore, such combinations must be chosen with care and tailored to theindividual.In addition to potency and susceptibility, important factors in the selection ofagents for any given patient are tolerability, convenience, and optimization ofadherence.Four classes of antiretroviral agents are available for use:1) Nucleoside/nucleotide reverse transcriptase inhibitors (nrtis)2) Nonnucleoside reverse transcriptase inhibitors (nnrtis),3) Protease inhibitors (pis)4) Fusion inhibitors.Importan

Review from student

Studypool Student
" Excellent work as usual "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1826 tutors are online

Other Documents


Brown University

1271 Tutors

California Institute of Technology

2131 Tutors

Carnegie Mellon University

982 Tutors

Columbia University

1256 Tutors

Dartmouth University

2113 Tutors

Emory University

2279 Tutors

Harvard University

599 Tutors

Massachusetts Institute of Technology

2319 Tutors

New York University

1645 Tutors

Notre Dam University

1911 Tutors

Oklahoma University

2122 Tutors

Pennsylvania State University

932 Tutors

Princeton University

1211 Tutors

Stanford University

983 Tutors

University of California

1282 Tutors

Oxford University

123 Tutors

Yale University

2325 Tutors