Pharmacology notes

Apr 15th, 2015
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Pharmacology notes

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TREATMENT OF MALARIA:Antimalarial drugs;1) 4 Methoxyquinolines;Quinine: 10mg / kg b.w per dose 8 hourly I.V or oral); severe infection Quinine + Clindamycin Quinine + Tetracycline Mefloquine + Artemisinin Mefloquine; used alone for prophylaxis2) 4 Aminoquinolines; Chloroquine Amodiaquine3) 8 Aminoquinolines; Primaquine for eradication of exoerythrocytic forms of P. Vivax,P. Ovale and gametocidal against P. Falciparum.(ADR: causes massive haemolysis in G 6PD def.)4)Sulphonamides combination;Sulfadoxine / Pyrimethamine e.g. FansidarSulphamethoxypyridazine / pyrimethamine e.g.Metakelfin5) Artemisinin derivatives from Artemisia annua;Artemether e.g. PalutherArtesunate; a semi-synthetic artemisinin e.g. arsumaxDihydroartemisinin; the active metabolite of artemisinine.g. cotecxinArtemether + lumefantrin = Coartem*Artesunate + Mefloquine = ArteqiunArtesunate + Amodiaquine = LarimalArtesunate + Sulphamethoxypyridazine + Pyrimethamine = Co-ArinateDihydroartemisinin + Piperaquine = Duo-cotecxinArtemisinin 62.5mg + Piperaquine 375mg = Artequick6) Biguanides & other combinations;Proguanil 100mg + Atovaquone 250mg = malaroneProguanil alone used only in prophylaxis7) 9 Phenanthrenemethanols;Halofantrine ( Halfan)lumefantrine; used only in combinationsAntimalarial drugs include;1)Quinine and related agents2)Chloroquine3)Amodiaquine4)Pyrimethami

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