Pharmacology notes

Apr 15th, 2015
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Pharmacology notes

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DRUG USED IN THE TREATMENT OF GOUTIt is important to distinguish the following in the management of gout;1) Management of the acute attack2) Long-term managementGouty Arthritis1) Management of the acute attack;An attack of acute gout is extremely painful and anti-inflammatory drugs shouldbe given at once. The drugs used are;1) NSAIDs such as indomethacin, naproxen, diclofenac, piroxicam,celecoxib and etericoxib in large doses for 24-48 hours.2) Colchicine; this drug can still be used in acute gout (orally orintravenously) or in the early months of treatment with allopurinol.ColchicineIndications; Colchicine is specifically indicated for treatment and relief of pain in attacks ofacute gouty arthritis. It is also recommended for regular use between attacks as a prophylacticmeasure, and is often effective in aborting an attack when taken at the firstsign of articular discomfort Colchicine is administered orally. For Acute Gouty Arthritis The usual dose to relieve or abort an attack is 1 to 1.5 mg (two 0.5 mggranules or three 0.5 mg tablets). This dose may be followed by one unit of either preparation (granule ortablet) every hour, or two units every two hours, until pain is relieved oruntil diarrhea ensues. The total amount of colchicine needed to control pain and inflammationduring an attack usually ranges from 4 to 8 mg.Clinical pharmacology;The exact mechanism of action of colchicine in gout is not co

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