Pharmacology notes

Apr 15th, 2015
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Pharmacology notes

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EU MBCHB 3 (Pharmacology II)DR D M KILLINGOPhysician / CardiologistThis left ventricle is very thickened (slightly over2 cm in thickness), but the rest of the heart is notgreatly enlarged. This is typical for hypertensiveheart disease. The hypertension creates a greaterpressure load on the heart to induce thehypertrophy.The left ventricle is markedly thickened inthis patient with severe hypertension that wasuntreated for many years. The myocardialfibers have undergone hypertrophy.See belowModulation of Renin ReleaseHigh bp assoc with decr LE, stroke, CAD, andother end-organ diseases (e.g., retinopathy,renal failure).Problem: Risk is graded.Lowering the bp is indicated in patients if thediastole bp> 90 mm Hg and systole bp> 160mm Hg.Other risk factors for vascular disease may besynergistic: smoking, obesity, hyperlipidemia,DM and ventricular hypertrophy.In cases of mild hypertension, weight loss,decr alcohol and salt may be sufficient, butIn more severe cases, drug treatment isindicated.-adrenergic receptor antagonistsThiazide diureticsACE inhibitorsCa2+ antagonists 1-adrenergic receptor antagonists?Centrally acting drugs: 2-adrenergicreceptor agonists?Moderate hypertention usually requires justone drug, but becoming incr more evidentthat >2 drugs will do the job better.One of 2 1st-line of defense in treatinghypertensionMech

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