Pharmacology notes

Apr 15th, 2015
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PHARMACOLOGIC MANAGEMENT OF PARKINSONISM &OTHER MOVEMENT DISORDERS:INTRODUCTIONSeveral types of abnormal movement are recognized.1) Tremor consists of a rhythmic oscillatory movement around a joint and is bestcharacterized by its relation to activity. Tremor at rest is characteristic of parkinsonism, when it is often associated withrigidity and an impairment of voluntary activity. Tremor may occur during maintenance of sustained posture (postural tremor) orduring movement (intention tremor).A conspicuous postural tremor is the cardinal feature of benign essential orfamilial tremor. Intention tremor occurs in patients with a lesion of the brainstem or cerebellum,especially when the superior cerebellar peduncle is involved, and may also occuras a manifestation of toxicity from alcohol or certain other drugs.2) Chorea consists of irregular, unpredictable, involuntary muscle jerks that occur indifferent parts of the body and impair voluntary activity.In some instances, the proximal muscles of the limbs are most severely affected,and because the abnormal movements are then particularly violent, the termballismus has been used to describe them. Chorea may be hereditary or may occur as a complication of a number of generalmedical disorders and of therapy with certain drugs.Abnormal movements may be slow and writhing in character (athetosis) and insome instances are so sustained that they are more properly regarded asabnormal

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