Pharmacology notes

Apr 15th, 2015
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CHOLERSTEROL AND LIPID LOWERINGDRUGSAim;The overall aim of lipid-modifying treatment is to reduce the circulating levels ofatherogenic lipids in order to slow, reverse or ideally prevent the development ofatherosclerotic vascular lesions and thereby reducing the long term risk ofcardiovascular disease.Evolution of obesityArtheromatous plaquesPathophysiology Cholesterol is a major component of lipid containing atherosclerotic plaques.Raising plasma levels of cholesterol and related lipid disturbances have beenidentified as a major risk factor (along with smoking and hypertension) foratherosclerotic cardiovascular disease and its consequences, particularlymyocardial infarction. Cholesterol is derived both from the diet and by endogenous synthesis in the liver. Cholesterol;o A component of all cell membraneso Precursor of steroid hormones, bile salts, glycoproteins and quinones The biochemistry and metabolism of cholesterol are complex. Cholesterol and other lipid fractions are transported in blood via lipoproteins ofdifferent densities. Increased total cholesterol and its major component fraction, LDL cholesterolhave been linked to accelerated atherosclerosis and increased coronary arterydisease. LDL cholesterol is cleared from the circulation by specific receptors on the cellsurface and the function of these receptors plays an important role indetermining the plasma levels of LDL cholesterol. HDL appears to

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