Pharmacology notes

Apr 15th, 2015
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ANTIPLATELET DRUGS;Approach to the management of thrombosis;Both Antiplatelet drugs and anticoagulants are effective in prevention of arterial, cardiac and venous thromboembolism.Antiplatelet drugs are preferred for routine cardiovascular prevention because they are less likely to cause excessive bleeding.Anticoagulants are however more effective in treatment of venous thromboembolism and peripheral arterial embolism and are indicated in specific circumstances such as atrial fibrillation.Thrombolytic agents have a main role in treatment of acute thrombotic arterial occlusion especially coronary thrombosis.ASPIRINPharmacology;All the pharmacological effects of aspirin are based upon inhibition of prostaglandin synthesis.Aspirin is used as an antiplatelet drug in doses lower than those employed for analgesia.Aspirin acetylates and inactivates cyclo-oxygenase, a key enzyme in the platelet biosynthetic pathway for the pro-aggregatory prostaglandin thromboxane A2.The interaction of aspirin with cyclo-oxygenase is irreversible. As platelets are anucleate, the recovery of thromboxane synthesis is dependent upon appearance of new platelet population in the circulation. Recove

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