Pharmacology notes

Apr 15th, 2015
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ANTIDEPRESSANT DRUGS Depression is a heterogeneous disorder that has been characterized and classified in avariety of ways. According to the American Psychiatric Association's modified fourth edition (2000) ofthe Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR), severaldiagnoses of affective disorders are possible. A simplified classification based on presumed origin is as follows:1) Brief reactive or secondary depression (most common), occurring in response toreal stimuli such as grief, illness, etc;2) Melancholic and recurrent depression, a genetically determined biochemicaldisorder manifested by an inability to experience ordinary pleasure or to copewith ordinary life events;3) Depression associated with bipolar affective (manic-depressive) disorder.The Pathogenesis of Major Depression: The Amine Hypothesis and SubsequentDevelopments Soon after the introduction of reserpine in the early 1950s, it became apparent thatthe drug could induce depression. Reserpine induced depression and depleted stores of amine neurotransmitters;therefore, it was reasoned, depression must be associated with decreased functionalamine-dependent synaptic transmission. This idea provided the basis for what became known as the amine hypothesis ofdepression. By extension, drugs that increased amine function in appropriate synapticareas would relieve depression. However current brain imaging and biochemical studies in patients do not s

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