Pharmacology notes

Apr 15th, 2015
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Wednesday, November 02, 2011ASTHMAMain symptoms includeWheezeCoughVariable breathlessnessReversible airflow obstruction>15% reversibility to inhaled bronchodilators>15% variability in peak flow rateThe disease is characterized by Respiratory tract inflammationIncreased eosinophils and mast cellsDamage to the airway epitheliumTherapy is aimed at minimizing symptoms when patients are stable and treating acute exacerbateOn XrayHyperinflated lungTubular mediastinumFlattened mediastinumMUST KNOW THE GINA CLASSIFICATION!!! DosingIt its very infrequent, use inhalers If its very frequent, give tabletsMyNB: constant inflammation are responsible for the bronchial thickening and luminal narrowingXRAY read; antieriorly, 6 ribs are supposed 2B visible, any more means air trapping. The 6th rib is supposed to tough the hemidiaphragm tip.XRAY Intepretation; start by IDing the Xray (name, hospital), soft tissue, bony cage, DayNightPEFR/FEVStage 1; Mild intermittent<2/wk<2/month>=80%Step 2; mild persistent>2/wk>2/month>=80%Step 3; mild persistentDaily>1/wk60-80%Step 4; severe persistentContinuousFrequent<60%TreatmentMild intermittentNo daily Tx neededMild persistentLow dose inhaled glucocorticoidModerate persistentInhaled glucocorticoids low dose + B2-agonistSevere persistentHigh dose inhaled glucocorticoids + long acting inhaled B2 agonists + glucocorticoid tablets.COPDThe features of COPD areExercise related bre

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