Pharmacology notes

Apr 15th, 2015
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GENERAL1. Differentiate betweena. pharmacokinetics & pharmacodynamics.b. Drug & medicinec. Agonist & partial agonist2. How is the effect of a competitive antagonist mitigated?3. What would make a dose response relationship curvea. Steep?b. Flat?4. Define therapeutic index; show it diagrammatically.5. Why are some drugs not administered orally? Give the factors determining bioavailability.6. Define bioavailability.7. Discuss; Apparent volume of distribution.a. Tissue binding versus plasma bindingb. Implications of high and low levels and lipid solubility8. Discuss Steady state Concentration and the analogy of troughs and peaks.9. What is clearance the sum total of?10. As a rule of thumb, in the absence of a loading dose, how long does it take to achieve normal CSS?11. Why would a patient with liver failure die from toxicity of a normal dose of drug T?12. What are the fates of the following drugsa. Water Solubleb. Fat soluble13. Discuss the group of drugs that area. Enzyme inducersb. Enzyme inhibitorsc. Explain why a woman on anti TB med, Rifampin conceived despite being on oral contraceptives.14. Comment on weak base and acid secretion in the kidney15. Discuss the different categories of drugs in pregnancies; comment where thalidomide & quinine may lie.Hypertension1. What are the differences between the following types of hypertensiona. Essentialb. Secondary2. Discuss the probable causes of secondary

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