Pharmacology notes

Apr 15th, 2015
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CLINICAL PHARMACOLOGY is the study of pharmacokinetics and pharmacodynamics of drugs.PHARMACOKINETICS; this is the description of drug concentration profile against time. Its application in clinical practice is called clinical pharmacokinetics.PHARMACODYNAMICS; this is the principle of study of drug action concerning residual variability of the relationship between dose and response; a measure of sensitivity of a patient to the drug.PHARMACODYNAMICSThis is the study of the principle of drug action.Pharmacological agents are used in therapeutics toCure diseases; chemotherapy in cancer or leukemia, antibiotics in specific bacterial infectionAlleviate symptoms; antacids in dyspepsia, NSAIDs in rheumatoid arthritisReplace deficiencies; Thyroxine (T4) in hypothyroidism, insulin in diabetes mellitusPrevent / delay end-stage consequences of degenerative diseases, aging etc.DRUG; a single chemical entity that may be one of the constituents of a medicine.MEDICINE; this may contain one or more active constituents (drugs) together with additives to facilitate administration.MECHANISM OF DRUG ACTIONAction on a receptorA receptor is a specific macromolecule usually a protein to which a specific group of drugs or naturally occurring substance (such as neurotransmitters or hormones) can bindAn agonist is a substance that stimulates or activates the receptor to produce effect e.g. salbutamol for B2 receptorsAn antagonist prevents the action of an agonist but do

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