Pharmacology notes

Apr 15th, 2015
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ASTHMA Main symptoms; Wheeze Variable breathlessness Cough Reversible air flow obstruction > 15% reversibility to inhaled bronchodilator > 15% variability in peak flow rate The disease is characterized by; Respiratory tract inflammation Increased eosinophils and mast cells Damage to the airway epithelium Therapy is aimed at minimizing symptoms when patients are stable andtreating acute exacerbation.COPD The features of COPD are; Exercise related breathlessness with relatively little day-to-day variability. Fixed airflow obstruction with little or no reversibility to bronchodilatortreatment. Cough with sputum production is a variable feature but prominent in somepatients. Histologically there may be destruction of the lung parenchyma (emphysema)and/or structural changes to the airway wall resulting in airflow obstruction. Therapy is aimed at maximizing any bronchodilator response that is present andtreating acute exacerbations. Greater than 90% of COPD is related to smoking. Lung function decline on average occurs 2-3 times more rapidly in smokers thanin non-smokers. Smoking cessation results in lung function decline to reverting tothe rate of non-smokers. Both asthma and COPD are common conditions and may co-exist.Peak Flow MetersPeak Flow MetersNebulizerNebulizerMDI- Metered Dose InhalerMDI- Metered Dose InhalerMDI- Metered Dose InhalerBron

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