Pharmacology notes

Apr 15th, 2015
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Pharmacology Semester 1 page 1 of 3By Duy Thai, 1997ADRENERGIC PHARMACOLOGY IV agonists Both 1 and 2 Isoprenaline Was the initial drug which helped identify the receptor from the receptor Not used clinically since it is not selective for 1 or 2 Since it is a catechol, it is readily metabolised by COMT in the tissues and gut andtherefore cannot be taken orally (it is taken sublingually) Is was once used as an antiasthmatic but is now superseded by salbutamol since it can alsoaffect the heart (increasing HR) Selective 1 agonist (1 found in heart and kidney) Dobutamide Is a very weak agonist Because of its weak action, it is good for use in people with heart failure (since we want amild stimulation of the heart) Selective 2 agonist (2 found in bronchi, uterus, skeletal blood vessels, liver) Salbutamol Main u

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