Pharmacology notes

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Pharmacology Semester 1 page 1 of 4By Duy Thai, 1997ANTI-INFLAMMATORY DRUGSInhibition of eicosanoid synthesis Corticosteroids Also known as steroidal anti inflammatory drugs Inhibits arachidonic acid release and metabolism. Inhibits both the production of prostinoids and leukotrienes by inhibiting phospholipase A2 More in the next lecture Non Steroidal Anti-inflammatory Drugs (NSAID) Inhibits cyclo-oxygenase (mainly COX1) Recall that COX1 is the constitutive enzyme which produces physiologically relevant prostaglandins. Itappears that we have inhibited the wrong COX - it would have been preferable to have inhibited COX2which is activated under pathological conditions. Since only COX is inhibited, synthesis of leukotrienes by lipoxygenase is unaffected. In fact, there may bea slight increase in leukotriene synthesis because we have more arachidonic acid present (since it is notbeing used up by COX).Uses of NSAIDS Anti pyretic Reduce fever Anti inflammatory Analgesic Reduce pain Anti aggregatory Reduce platelet plug and clot formationExamples of NSAIDsCOX inhibition11002000AspirinIndomethacinMeclofena

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