Pharmacology notes

Apr 15th, 2015
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Pharmacology Semester 1 page 1 of 4By Duy Thai, 1997ARACHIDONIC ACID METABOLITES The 3 main groups of arachidonic acid metabolites are: Prostaglandins (PG) Leukotrienes (LT) Platelet activating factor (PAF) Arachidonic acid is one of 3 essential fatty acids An essential fatty acid is one that cannot be formed de novo. It must be obtained from the diet The essential fatty acids required by us are: Eicosatrienoic acid - 3 Eicosatetranoic acid - 4 Eicosapentanoic acid - 5 Arachidonic acid is not a circulating compound, nor does it have any intrinsic biological activity. Arachidonic acid is incorporated into phospholipids which make up the membranes of all cells. Hence, arachidonic acid is present in all cells of the body The first step in the metabolism of arachidonic acid is the removal of it from the phospholipid. This step is done by phospholipase A2 or C. The following is the outcome of this first step:PhospholipidsPhospholipase (A2 or C)Arachidonic acidCyclo-oxygenaseProstinoidsThromboxaneLipoxygenaseLeukotrienesProstaglandinsThe prostinoids The prostinoids are derived from arachidonic acid af

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