Pharmacology notes

Apr 15th, 2015
Studypool Tutor
Price: $5 USD

Tutor description

Word Count: 1960
Showing Page: 1/6
By Duy Thai: www.geocities.com/d.thai1997 Pharmacology Semester 1 page 1 of 6ENZYMES AS SITES OF DRUG ACTION ITargets of drug action Drugs which are developed can act on 4 types of proteins: Surface receptors Ion channels Transporters/carriers Enzymes The reasons why proteins (and I will refer specifically to enzymes here) make good targets is because: They have high structural specificity Tissue specific expression Species differences in enzyme properties. Although the enzyme may have the same name and same function, there are slight chemicaldifferences between species which is exploited by species specific drugs. Enzymes act as catalysts for reactions Some enzymes work in cascade reactions. We must target the rate limiting enzyme because this enzyme limits the rate of all the otherenzymes in the reaction cascade. Isoforms Most enzymes have more than one isoform. The development of drugs which target specific isoforms can help in: Improving tissue selectivity Reducing side effects.Mechanisms by which drugs interact with an enzyme Competitive inhibitors Bind to the same binding site as the substrate. Binding is surmountable Non-competitive inhibitors Does not bind to the same binding site as the substrate. Pseudo-irreversible inhibitors Have high affinity to an enzyme and a slow off rate. The binding is non-covalent but because the affinity isso strong, they can be con

Review from student

Studypool Student
" Excellent work as usual "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1827 tutors are online

Other Documents

04/15/2015
04/15/2015
04/15/2015
04/15/2015
04/15/2015
04/15/2015
04/15/2015
04/15/2015
04/15/2015
04/15/2015

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors