Pharmacology notes

Apr 15th, 2015
Studypool Tutor
Price: $5 USD

Tutor description

Word Count: 1960
Showing Page: 1/6
By Duy Thai: Pharmacology Semester 1 page 1 of 6ENZYMES AS SITES OF DRUG ACTION ITargets of drug action Drugs which are developed can act on 4 types of proteins: Surface receptors Ion channels Transporters/carriers Enzymes The reasons why proteins (and I will refer specifically to enzymes here) make good targets is because: They have high structural specificity Tissue specific expression Species differences in enzyme properties. Although the enzyme may have the same name and same function, there are slight chemicaldifferences between species which is exploited by species specific drugs. Enzymes act as catalysts for reactions Some enzymes work in cascade reactions. We must target the rate limiting enzyme because this enzyme limits the rate of all the otherenzymes in the reaction cascade. Isoforms Most enzymes have more than one isoform. The development of drugs which target specific isoforms can help in: Improving tissue selectivity Reducing side effects.Mechanisms by which drugs interact with an enzyme Competitive inhibitors Bind to the same binding site as the substrate. Binding is surmountable Non-competitive inhibitors Does not bind to the same binding site as the substrate. Pseudo-irreversible inhibitors Have high affinity to an enzyme and a slow off rate. The binding is non-covalent but because the affinity isso strong, they can be con

Review from student

Studypool Student
" Very Satisfied. "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1821 tutors are online

Other Documents


Brown University

1271 Tutors

California Institute of Technology

2131 Tutors

Carnegie Mellon University

982 Tutors

Columbia University

1256 Tutors

Dartmouth University

2113 Tutors

Emory University

2279 Tutors

Harvard University

599 Tutors

Massachusetts Institute of Technology

2319 Tutors

New York University

1645 Tutors

Notre Dam University

1911 Tutors

Oklahoma University

2122 Tutors

Pennsylvania State University

932 Tutors

Princeton University

1211 Tutors

Stanford University

983 Tutors

University of California

1282 Tutors

Oxford University

123 Tutors

Yale University

2325 Tutors