Pharmacology notes

Apr 15th, 2015
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1997 Pharmacology Semester 1 page 1 of 3By Duy Thai: www.geocities.com/d.thaiDRUG ABSORBPTIONDrug absorptionIn order for a drug to be absorbed, it must be able to pass through cell membranes (which is a lipid barrier).Lipid soluble drugs would be ideal to pass through the membrane easily, but not all drugs can be lipid solubleto a great extent. There are 4 main ways drugs can be absorbed:1. Lipid diffusion2. Aqueous diffusion3. Coabsorption with lipids4. Facilitated diffusion/active transportLipid diffusion Highly lipid soluble drugs are able to pass across cell membranes quite easily. The movement is driven bypassive diffusion down a concentration gradient. The lipid partitioning coefficient is a numerical value of how lipid soluble a drug is.[lipid ]P=[H 2 O] If the concentration of the drug is higher in a lipid medium than in an aqueous medium, it wil

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