Pharmacology notes

Apr 15th, 2015
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1997 Pharmacology Semester 1 page 1 of 4By Duy Thai: METABOLISM 1Drug metabolism Biotransformation is the same as metabolism. Metabolism of a drug involves the modification of a drug via its interaction with endogenous metabolic enzymes. These enzymes were not designed to handle the drugs specifically. They were designed to metabolise endogenouschemicals, not artificial drugs. It just so happens that the enzymes choose to accept a drug as being a substrate. Theenzymes are not very selective. Hence, there is competition for enzymes. Say we have enzyme A. Substance A is the normal endogenous substrate for enzyme A. We now have a drug (drug 1) which can act as a substrate for enzyme A. Drug 1 and substance A will compete for the enzyme. Hence, the physiological condition of a patient mayaffect the metabolism of drug 1 because of varying levels of substance A in the body. If there is lots of substance A, then metabolism of drug 1 will be reduced and vice versa. If another drug is added (drug 2) which is also a substrate for this same enzyme, we get a 3 waycompetition for the enzyme. Hence, when giving drug co

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