Pharmacology notes

Apr 15th, 2015
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Pharmacology Semester 1 page 1 of 4By Duy Thai, 1997PERIPHERAL PEPTIDE HORMONESLow molecular weight transmitters Noradrenaline AdrenalineNeuropeptides Substance P (pain transmission) Opiods (pain modulation)Vasoactive peptides (hormones) Angiotensin (BP control) BradykininANGIOTENSIN IIThe renin angiotensin system The R-A system is involved in homeostatic control of blood pressure and fluid and electrolyte balance. If there is a decrease in blood pressure and/or Na in the blood, various autonomic reflexes are enabled to bringthings back to normal. A fall in blood pressure causes the baroreceptors to activate sympathetics Sympathetic activation causes increased cardiac output and peripheral vasoconstriction. Sympathetic nerves innervating the kidney stimulates the release of renin from the juxtaglomerular cells(beta 1 receptor). The release of renin is also mediated by: The afferent arteriole sensing a decrease in stretch (less blood flow) The macula densa sensing a decreased Na load.Renin cleaves angiotensinogen to angiotensin I.Angiotensin I is converted to angiotensin II via Angiotensin

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