pharmacology notes

Apr 16th, 2015
Studypool Tutor
Price: $5 USD

Tutor description

Word Count: 421
Showing Page: 1/12
ANTIRETROVIRALSNONNUCLEOSIDE REVERSE TRANCRIPTASEINHIBITORS(NNRTIs)BYTOBIAS OMONDIMBchB IVUEEXAMPLES1. Efavirenz2. Nevirapine3. Delavirdine4. Etravirine: Is the newest NNRTI approved for treatmentof experienced HIV patients May be effective against HIV strains resistantto other drugs in this groupMODE OF ACTIONThey inhibit HIV-reverse transcriptase by binding at asite remote from the active site(this site is differentfrom the binding site of NRTIs)They produce conformational change in theenzyme that prevents substrate bindingNNRTIs do not require phosphorylation to beactive and do not compete with nucleosidetriphosphatesThere is no cross-resistance with NRTIsRESISTANCEResistance emerges rapidly by single pointgene mutations(mutations occur in the polgene, and is rapid if these agents are used asmonotherapy)PHARMACOKINETICSEFAVIRENZ:Oral absorption is less goodFatty foods may enhance its oralbioavailabilityCan be given once daily because of its longhalf life of two daysEFV is metabolized by hepatic cytochromeP450PharmacokineticsNEVIRAPINE:Oral absorption is very good with good oralbioavailabilityPenetrates most tissues including the CNSHas a half life of more than 24hoursMetabolized by the hepatic cytochrome P450cyp3A4 isoformUsed in combination regimensIs effective in prevention of vertical HIVtransmission when given as a single dose tomothers at the ons

Review from student

Studypool Student
" Very Satisfied. "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1830 tutors are online

Brown University





1271 Tutors

California Institute of Technology




2131 Tutors

Carnegie Mellon University




982 Tutors

Columbia University





1256 Tutors

Dartmouth University





2113 Tutors

Emory University





2279 Tutors

Harvard University





599 Tutors

Massachusetts Institute of Technology



2319 Tutors

New York University





1645 Tutors

Notre Dam University





1911 Tutors

Oklahoma University





2122 Tutors

Pennsylvania State University





932 Tutors

Princeton University





1211 Tutors

Stanford University





983 Tutors

University of California





1282 Tutors

Oxford University





123 Tutors

Yale University





2325 Tutors