pharmacology notes

Apr 16th, 2015
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Antiretroviral Therapy:PharmacologyCristina Gruta, PharmD,Asst. Clinical Professor of ClinicalPharmacy and FCMSan Francisco AIDSEducation and TrainingCenterHIV Life CycleStep 1: FusionHIVStep 3:IntegrationreversetranscriptaseStep 5: Packagingand BuddingStep 2: TranscriptionStep 4: CleavageNucleoside Analogues (NAs) orNRTIsAbbreviatedNameAZTGeneric NameTrade Name DoseZidovudineRetrovirddIDidanosineVidexddCZalcitibineHividd4TStavudineZerit3TCLamivudineEpivir20 mg BID40 mg BID150 mg BIDCombivirOne BIDZiagen300 mg BIDTrizivirOne BIDAZT/3TCABCAZT/3TC/ABCAbacavir200 mg TID300 mg BID200 mg BID400 mg QD0.75 mg TIDNucleoside Analogues: FoodConstraintsddI (didanosine/Videx) only one that requiresan empty stomach, i.e. at least one hour beforeor two hours after a mealFor buffered tablets, need at least two tabs/dose foradequate buffering capacityEnteric-coated still requires empty stomachAll other NRTIs can be taken with food bestfor GI tolerabilityNucleotide AnaloguesTenofovir (VireadTM), TFVDose: 300 mg once dailyTake with food for optimal absorptionNucleoside/Nucleotide Analogues:Common Adverse EffectsAZT: HAs, n/v, fatigue, bonemarrow suppressionddI, ddC, d4T: peripheralneuropathy, pancreatitis3TC: HAs, nausea (generallywell-tolerated)Abacavir (ABC): n/v/d,perioral paresthesias,hy

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