pharmacology notes

Apr 16th, 2015
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1ANTIVIRAL AGENTSINTRODUCTION2Viruses are obligate intracellular parasites.Replication depends on the syntheticprocesses of the host cell.:. Antiviral agents must either block entry intothe cell or be active inside the cell to beeffective.Contd.3Viral replication peaks at or before themanifestation of clinical symptoms.Optimal efficacy depends on early initiationtherapy or prevention of infection.Contd41.2.3.4.5.Viral replication:Adsorption and penetration into susceptiblehost cellsUncoating of viral nucleic acidSynthesis of early, regulatory proteins eg.Nucleic acid polymerasesSynthesis of RNA or DNASynthesis of late, structural proteinsContd56. Assembly (maturation) of viral particles7. Release from the cellClassification61.Agents used to treat HSV and VZVAcyclovirValacyclovirFamciclovirForscanetPenciclovir - topicalDocosanol - Trifluridine - Contd72. Agents used in the treatment of CMV Valganciclovir Ganciclovir Cidofovir ForscanetContd83. Anti-influenza agents Amantadine Rimantadine Zanamivir OstelamivirAntiherpes agents1. Acyclovir9An acyclic guanosine derivative with clinicalactivity against HSV 1 and 2 and against VZV.Weaker against EBV, CMV HSV 6.Mechanism of action10Requires 3 phosphorylation steps foractivation.1st to be converted to the mono

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