pharmacology notes

Apr 16th, 2015
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Anyika celpher Amprenavir Atazanavir Fosamprenavir Indinavir Lopinavir/ Neflinavir Ritonavir Saquinavir TipranarRitonavir Inlater stages of HIV growth cycle Gag andGag pol gene are translated into polyproteinswhich become immature budding noninfectious viral particles. Protease enzyme is required for cleavingthe precursor molecules to produce the finalstructural proteins of the mature virion core. PI prevent the Gag-pol polyprotein cleavagehence production of immature non-infectiousviral particles.. Specificgenotype alterations that conferphenotypic resistance are fairly commonwith these agents hence monotherapy iscontraindicated. Combination therapy with maximallyefficacious and potent agents will there4reduce viral replication and the likelihood ofresistance development. The HAART therapy comprises of 3-4 ARVsThe use use of all PI with an exception ofatazanavir is associated with a syndrome ofredistribution and accumulation of body fat thatresults in central obesity, dorsocervical fatenlargement (buffalo hump), peripheral andfacial wasting, breast enlargement, and acushingoid appearance. Concurrent increases in triglyceride and LDLlevels, along with glucose intolerance and insulinresistance, have also been noted. The cause isunknown. spontaneous bleeding in patients withhemophilia A or B.Cushingoid illustrations.Buffalo humpFacial wastingcentralOb

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