Internal medicine notes

Apr 16th, 2015
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PANCREATITISDR ANN MULIDEFINITIONPancreatitis - inflammation of the pancreas.CLASSIFICATIONSeither acute or chronic. Acute pancreatitis refers to an acute inflammationthat resolves both clinically and histologically Chronic pancreatitis is characterizedbyirreversible histologic changes that persist evenafter the cause has been removed. The histologic changes in chronic pancreatitis tendto progress, resulting in serious loss of exocrineand endocrine pancreatic function and deteriorationof pancreatic structure.ANATOMY & PHYSIOLOGYThe pancreas is a gland located in the upper,posterior abdomen and is responsible for insulinproduction (endocrine pancreas) & themanufacture and secretion of digestive enzymes(exocrine pancreas) leading to carbohydrate, fat,and protein metabolism. Approximately 80% of the gross weight of thepancreas supports exocrine function, while theremaining 20% is involved with endocrine function.ANATOMY & PHYSIOLOGY.Enzymes are produced within the pancreatic acinarcells, packaged into storage vesicles calledzymogens, and then released via the pancreaticductal cells into the pancreatic duct, where they aresecreted into the small intestine to begin themetabolic process up to 15 different types of digestive enzymes aremanufactured in the rough endoplasmic reticulum,targeted in the golgi apparatus & packaged intozymogens as pro-enzymes.CONT,When a meal is ingested, the vagal nerves, VIP,

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