Internal medicine notes

Apr 16th, 2015
Studypool Tutor
Price: $10 USD

Tutor description

Word Count: 811
Showing Page: 1/32
Inflammatory BowelDiseaseInflammatory bowel diseaseUlcerative colitis- diffuse mucosal inflammation- limited to colon- defined by location (eg proctitis;pancolitis)Crohns disease-patchy transmural inflammationfistulae; stricturesany part of GI tractdefined by location or patternTreatment options1. MOA unknownact on epithelial cells; anti-inflammatorymodulate release of cytokines and reactiveoxygen speciesSulphasalazineSulfapyridine + 5-aminosalicylic acidCleaved in colon by bacterial action5-ASA poorly absorbed active moietySulfapyridine absorbed side effectsNewer formulationsMesalazine (5-ASA)Balsalazide (a prodrug of 5-ASA)Olsalazine (5-ASA dimer)Pharmacological propertiesOral; enema; suppositories PH dependent release/resin coated(eg Asacol; caution with lactulose Ph) Time controlled release (eg Pentasa) Delivery by carrier molecules (egSulphasalazine;olsalazine;balsalazide)IndicationsMaintaining remission in UCReduce risk of colorectal cancer by 75%(long term Rx for extensive disease)Less effective for maintenance in CDInducing remission in mild UC/CD(higher doses)Contraindications/cautions5-ASA- Salicylate hypersensitivitySulfapyridine- G6PD deficiency (haemolysis)- Slow acetylator

Review from student

Studypool Student
" Excellent work as always thanks so much "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1824 tutors are online

Other Documents


Brown University

1271 Tutors

California Institute of Technology

2131 Tutors

Carnegie Mellon University

982 Tutors

Columbia University

1256 Tutors

Dartmouth University

2113 Tutors

Emory University

2279 Tutors

Harvard University

599 Tutors

Massachusetts Institute of Technology

2319 Tutors

New York University

1645 Tutors

Notre Dam University

1911 Tutors

Oklahoma University

2122 Tutors

Pennsylvania State University

932 Tutors

Princeton University

1211 Tutors

Stanford University

983 Tutors

University of California

1282 Tutors

Oxford University

123 Tutors

Yale University

2325 Tutors