Pathology notes

Apr 16th, 2015
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Myeloproliferative disordersTitoDepartment of HematologyIntroductionHemopoietic stem cell disorderClonalCharacterized by proliferationGranulocyticErythroidMegakaryocyticInterrelationship betweenPolycythaemiaEssential thrombocythaemiamyelofibrosisIntroduction / haemopoiesisIntroductionNormal maturation (effective)Increased number ofRed cellsGranulocytesPlatelets(Note: myeloproliferation in myelodysplastic syndrome is ineffective)Frequent overlap of the clinical, laboratory &morphologic findingsLeucocytosis, thrombocytosis, increasedmegakaeryocytes, fibrosis & organomegaly blurs theboundariesHepatosplenomegalySequestration of excess bloodExtramedullary haematopoiesisLeukaemic infiltrationRationale for classificationClassification is based on the lineageof the predominant proliferationLevel of marrow fibrosisClinical and laboratory data (FBP, BM,cytogenetic & molecular genetic)Differential diagnosisFeatures distinguishing MPD from MDS, MDS/MPD & AMLDiseaseBMcellularity%marrowblastsMaturationMorphologyHaemato-poiesisBloodcountsLargeorgansMPDIncreasedNormal or< 10%PresentNormalEffectiveOne ormoremyeloidincreasedCommonMDSUsuallyincreasedNormal or< 20%PresentAbnormalIneffectiveLow oneor morecytopeniaUncommonMDS/MPDUsuallyincreasedNormal or<20%Present

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