Pathology notes

Apr 16th, 2015
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COAGULATIONSCREENINGLUCY NJUGUNAoverviewHemostasis Endothelium Platelets Coagulation cascadeTESTS1. countBleeding timeProthrombin ratioActivated partial thrombin timeFibrinogen assaySpecific factor assaysFibrin degradation productsD-dimerThrombin time7. Specific factor inhibitor assaysProtein CTFPIAnti-thrombin IIIOTHER TESTSLFTs1 . Platelet countMETHOD- hematocytometerNormal 150,000-400,000 cells/ulTHROMBOCYTOPENIADecreased prodxn: Vitamin B 12/ folate deficiency Leukemia/ myelodysplastic syndrome Liver failure (thrombopoietin prodxn isdecreased) Dengue fever direct infection of BM megakaryocytes, immunological shortened platelet survival.Hereditary syndromes congenital amegakaryocytic thrombocytopenia Fanconi anemiaIncreased destruction idiopathic thrombocytopenic purpura Thrombotic thrombocytopenic purpura HUS DIC SLE Post-transfusion purpura hypersplenismMedication-inducedDirect myelosuppression methotrexate2. Bleeding timeassess platelet functionIvy method shallow incision that is 1mm deep on theventral side of the forearm. Normal values: 3 10 minutesDuke Method the patient is pricked with a special needle orlancet, preferably on the earlobe or fingertip ,after having been swabbed with alcohol. The prick is about 34 mm deep. The usual ti

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