Pathology notes

Apr 16th, 2015
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INVESTIGATION OFHAEMOSTATIC FUNCTIONChumba K. DennisFUNCTIONs OF HAEMOSTATICMECHANISM Promote local haemostasis at the site of injuredbloodvessel Ensure circulating blood remains in fluid state and preventthrombosisFormation of haemostatic plug is a complex mechanism andinvolves mantainance of a delicate balance among atleast 5components.....{I}.Blood vessel wall {II}Platelets {III}Plasmacoagulation factors {iv]inhibitors;and {v}Fibrinolytic system.Anythingthatinterfereswithanyofthesecomponentsresultsindefectivehemostasiswithabnormalbleeding.Inordertoestablishadefinitediagnosisinanycasesuspectedtohaveabnormalhemostaticfunctions,thefollowingschemeisfollowed:A.Comprehensiveclinical evaluation, includingthepatientshistory,familyhistoryanddetailsofthesite,frequencyandcharacterofhaemostaticdefect.B.Seriesofscreening tests forassessingtheabnormalitiesinvariouscomponentsinvolvedinmaintaininghaemostaticbalance.C.Specific tests topinpointthecause.AbriefreviewofgeneralprinciplesoftestsusedtoinvestigatehemostaticabnormalitiesA. Investigation of Disordered Vascular HaemostasisDisordersofvascularhaemostasismaybeduetoincreasedvascularpermeability,reducedcapillarystrengthandfailureA.Investigation of Disordered Vascular HaemostasisDisorders of vascular haemostasis may be du

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