Pathology notes

Apr 16th, 2015
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MBchB YEAR THREE(2013/2014)PRESENTATIONONFLUORESCENCE INSITU HYBRIDIZATIONBYOMONDI OCHOLA TOBIASEGERTON UNIVERSITYFISH Is a cytogenic technique developed by biomedicalresearchers in the early 1980s,that is used to detect andlocalize the presence or absence of specific DNA sequenceon chromosomes. FISH uses fluorescence probes that bind to only those partsof the chromosome with which they show a high degree ofsequence complementarity. Fluorescence probe : Also known as hybridization probe, is afragment of DNA or RNA of variable length(usually 100 to1000 bases long) which is used in DNA or RNA samples todetect the presence of nucleotide sequence(DNA target)that are complementary to the sequence in the probe. Fluorescence microscopy can be used to find out where thefluorescence probe is bound to the chromosomes.USES OF FISH To find specific features in DNA for use in, geneticcounseling,medicine,and species identification. To detect circulating tumour cells and tissue sample; hencehelp in1. Categorizing undifferentiated malignant tumours,2. Determination of site of origin of metastatic tumours,3. Detection of molecules that have progno

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