Pathology notes

Apr 16th, 2015
Studypool Tutor
Price: $5 USD

Tutor description

Word Count: 1184
Showing Page: 1/14
ARTHRITISMUTHONI MARYJoint disordersDegenerativeInfectionImmune-mediated injuryMetaboric derangementsNeoplasmsARTHRITISOsteoarthritisInfective arthritisRheumatoid arthritisOSTEOARTHRITISIts a degenerative joint dse ; part of aging and an important cause of disability in individuals60yrscharacterstic feature degeneration of articular cartilage (not inflammation ). Any structuralchanges in the underlying bone are secondary.Most osteoarthritis appears insidiously with age and w/out any initiating cause ; in such casesits oligoarticular- called primary OAIf it strikes in youth, theres an underlying cause ; previous traumatic injury, developmentalinjury or underlying systemic dse (DM,ochronosis,hemochromatosis and marked obesity) - calledsecondary OAMORPHOLOGY Earliest structural changes- enlargement, proliferation and disorganization ofchondrocytes in superficial part of the articular cartilage; accompanied by increasedwate content of matrix and reduced prostagrandin concentration.NB prostagrandin conveys turgor and elasticity.Consequently vertical and horizontal fibrillation and cracking of matrix occurs as thesuperficial layers of the cartilage are degraded.Gross examination- soft granular articular cartilage surface. Eventually full thicknessportions of cartilage are lost and the subchondral bone plate is exposed.Friction smooths

Review from student

Studypool Student
" This tutor is great! "
Ask your homework questions. Receive quality answers!

Type your question here (or upload an image)

1829 tutors are online

Other Documents


Brown University

1271 Tutors

California Institute of Technology

2131 Tutors

Carnegie Mellon University

982 Tutors

Columbia University

1256 Tutors

Dartmouth University

2113 Tutors

Emory University

2279 Tutors

Harvard University

599 Tutors

Massachusetts Institute of Technology

2319 Tutors

New York University

1645 Tutors

Notre Dam University

1911 Tutors

Oklahoma University

2122 Tutors

Pennsylvania State University

932 Tutors

Princeton University

1211 Tutors

Stanford University

983 Tutors

University of California

1282 Tutors

Oxford University

123 Tutors

Yale University

2325 Tutors