Pathology notes

Apr 16th, 2015
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Peter Kinyanjui..HEMATOPOIETIC SITESEmbronic periodFrom 2nd wkYolk sac3rd month to first2wks after birthLiver and spleen4th & 5th monthcommencement in the BM,becomes fully activeby 7th & 8th monthsChildhood & adultlifeBM. The spleen and liver can also resume their foetalhaematopoietic role in certain pathologic conditionsand is called extramedullary haematopoiesis. In the bone marrow, developing blood cells aresituated outside the marrow sinuses, from where aftermaturation they enter the marrow sinuses, the marrowmicrocirculation and thence released into circulation.HEMATOPOIETIC STEM CELLSHaematopoieisis involves two stages:mitotic division or proliferation, anddifferentiation or maturationas CD34 and adhesion proteins which help the stemcells to home to the BM when infused. The stem cells have the appearance of small orintermediate-sized lymphocytes and their presence inthe marrow can be demonstrated by cell culturetechniques by the growth of CFU pertaining todifferent cell lines The bone marrow provides a suitable environment forgrowth and development of stem cells The stem cells have the capability of maintaining theirprogeny by self-replication. stem cells express a variety of cell surface proteins such. Myeloid haematopoiesis is regulated by endogenousglycoproteins called as growth factors, cytokines andhormonesErythropoietinGranulocyte colony-stimulating fact

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