Pathology notes

Apr 16th, 2015
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Cardiac BiomarkersMBChB level IIIDr. Wangari WambuguCaseA 54 year female known type 2 diabeticpatient presents to the ER with a 2-dy historyof intermittent left-sided chest pain radiatingto the left shoulder that had worsened in theprevios 6-hrs. She has been attending adiabetic clinic and glucose levels are reportedto be well-controlled on oral hypoglycaemics.Investigations ??CaseECG-doneTests ordered:Blood glucoseHb1cCardiac enzymesu/e/c, CRP, urinalysis, lipid profileLearning objectivesAt the end of this lecture the student will beable to:Recognize various cardiac biomarkers.Define the newly applied markersApply the guidelines in diagnosis of MyocardialinfarctionDefine the markers of IschemiaIdentify the markers of Heart failureCardiac biomarkersDefn:A substance released from the heart muscle when itsdamaged as a result of myocardial infarction or minormyocardial injury.Plays a major role in diagnosis of acute myocardialinfarctionNewer biomarkers have extended the use ofbiomarkers beyond the diagnosis of cardiac necrosisUniversal Definition of Myocardial InfarctionJoint ESC/ACCF/AHA/WHF Task ForceCirculation. 2007 Nov 27;116(22):2634-53.6Ideal cardiac biomarkerAbsolute cardiac specificitySpecific for irreversible injuryEarly releaseHigh tissue sensitivityStable releasePredictable clearanceCom

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