Pathology notes

Apr 16th, 2015
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THE PANCREASPrepared by RONO Endocrine-glugagon,somatostatin,insulin Exocrine-produce digestive enzymes ininactive form except amylase andlipase.Stored in zymogen granules. Cuboidal epithelial cells lining the smallerducts secrete bicarbonate rich fluid. Columnar cells in larger ducts-mucin andexpreses the cystic fibrosis conductanceregulator(CTTR) Activation of proenzymes reguires conversionof trypsinogen to trypsin by duodenalenteropeptidase(enterokinase) Trypsin inhibitors-trypsin protein inhibitortype 1(SPINK1) are also secreted by acinar andductal cells. Acinar cells are remarkably resistant to theaction of activated enzymes egtrpsin,chymotrypsin and phospholipase A2.CONGENITAL ANOMALIES1.Agenesis.2.Pacreas divisum.-Failure of the featal duct systems of thepancreatic primordia to fuse.-The relative stenosis caused by the bulk of thepancreatic secresions passing through theminor sphincter predisposes such individualsto chronic pancreatitis.3.Annular pancrease.4.Ectopic pancreas-mostly in stomach andduodenum.5.Congenital cyst-from anomalouse ductdevelopment.PANCREATITIS Infam of the pancrease.ACUTE-can return to normal if the cause ofinflam is removed.CHRONIC-presense of irreversible destruction ofexocrine pancreatic parenchyma.ACUTE PANCREATITIS Severity can range from focal edema and fatnecrosis to widespread parenchymal necrosiswith severe hemorrhage. 80%-due to biliary dse or alco

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